GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs10819861 | 1 | rs10819861 | chr9:98867813 | C9orf102 | chr9:98637900-98767136:+ | -0.1 | -4.79 | 1.94E-6 | Electrocardiographic traits |
| BRCA | cis | rs10819861 | 1 | rs10819861 | chr9:98867813 | C9orf130 | chr9:98568372-98638259:- | -0.19 | -5.63 | 2.37E-8 | Electrocardiographic traits |
| BRCA | cis | rs10822145 | 1 | rs10822145 | chr10:64934548 | NRBF2 | chr10:64893007-64914785:+ | -0.16 | -5.72 | 1.39E-8 | Triglycerides |
| BRCA | cis | rs7923609 | 1 | rs10822149 | chr10:64987412 | NRBF2 | chr10:64893007-64914785:+ | -0.16 | -5.89 | 5.31E-9 | Educational attainment;Liver enzyme levels (alkaline phosphatase) |
| BRCA | cis | rs7923609 | 1 | rs10822161 | chr10:65118203 | NRBF2 | chr10:64893007-64914785:+ | -0.16 | -5.84 | 6.91E-9 | Educational attainment;Liver enzyme levels (alkaline phosphatase) |
| BRCA | cis | rs7923609 | 1 | rs10822163 | chr10:65124098 | NRBF2 | chr10:64893007-64914785:+ | -0.16 | -5.84 | 6.91E-9 | Educational attainment;Liver enzyme levels (alkaline phosphatase) |
| BRCA | cis | rs12277962 | 1 | rs10832821 | chr11:17658845 | PIK3C2A | chr11:17099277-17229530:- | -0.11 | -3.48 | 0.000522 | Night sleep phenotypes |
| BRCA | cis | rs12277962 | 1 | rs10832821 | chr11:17658845 | RPS13 | chr11:17095940-17099220:- | -0.15 | -3.85 | 0.000124 | Night sleep phenotypes |
| BRCA | cis | rs9783347 | 1 | rs10832921 | chr11:18380835 | GTF2H1 | chr11:18343816-18388590:+ | 0.31 | 8.38 | 1.68E-16 | Pancreatic cancer |
| BRCA | cis | rs10160456 | 1 | rs10835152 | chr11:27311217 | LGR4 | chr11:27387510-27494334:- | 0.14 | 4.16 | 3.49E-5 | Bone mineral density (paediatric, skull) |
| BRCA | cis | rs10160456 | 1 | rs10835153 | chr11:27313863 | LGR4 | chr11:27387510-27494334:- | 0.14 | 4.11 | 4.25E-5 | Bone mineral density (paediatric, skull) |
| BRCA | cis | rs10160456 | 1 | rs10835154 | chr11:27315356 | LGR4 | chr11:27387510-27494334:- | 0.14 | 4.11 | 4.18E-5 | Bone mineral density (paediatric, skull) |
| BRCA | cis | rs10160456 | 1 | rs10835155 | chr11:27317812 | LGR4 | chr11:27387510-27494334:- | 0.14 | 4.12 | 4.16E-5 | Bone mineral density (paediatric, skull) |
| BRCA | cis | rs10160456 | 1 | rs10835156 | chr11:27325218 | LGR4 | chr11:27387510-27494334:- | 0.14 | 4.15 | 3.57E-5 | Bone mineral density (paediatric, skull) |
| BRCA | cis | rs10160456 | 1 | rs10835157 | chr11:27325462 | LGR4 | chr11:27387510-27494334:- | 0.14 | 4.08 | 4.75E-5 | Bone mineral density (paediatric, skull) |